House received a 2005 Peabody Award for what the Peabody board called an "unorthodox lead character – a misanthropic diagnostician" and for "cases fit for a medical Sherlock Holmes," both of which helped make House "the most distinctive new doctor drama in a decade."[citation needed] At the 2005 American Film Institute Awards, House was an official selection as TV Program of the Year. House was nominated for the 2008 Golden Globe Award for Best Television Series - Drama but lost to Mad Men.

Creator David Shore won a writing Emmy in 2005 for the first season episode "Three Stories".Writer Lawrence Kaplow won a Writers Guild of America Award in 2006 for his season two episode "Autopsy".

In 2005 and 2007, lead actor Hugh Laurie was nominated for an Emmy Award for Outstanding Lead Actor in a Drama Series. He was awarded the Golden Globe for Best Actor in a Television Drama in 2006 and again in 2007, when he also won the Screen Actors Guild Award for Outstanding Performance by a Male Actor in a Drama Series. Laurie was nominated for Best Actor in a Television Drama again for the 65th Golden Globe Awards but lost to Jon Hamm.

 
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